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Lisinopril hctz medication (R), hlofurser (R) and zidovudine at 0, 0.5, 1 or 2 mg/kg vehicle, respectively. The animals received repeated doses of the test drugs, separated by 10 days. The animals were sacrificed on third or the fifth day after drug administration, whichever came first. Results Protein content and morphology analysis As well a decrease in the protein content of liver, a significant loss in the size of liver mass can be detected in a treated group using the method described by Li et al.16 There was no significant change of the total RNA content liver tissues in the treated group. Changes in the mRNA levels of genes known for liver antioxidant, such as superoxide dismutase, catalase and glutathione peroxidase18 were observed only in the treated animals. Superoxide dismutase and catalase have previously been implicated as liver antioxidants by us21 and Zhang et al.22, respectively. However, our in vitro experiment proves that these gene changes remain intact in the protein content of liver tissue after administration the tested drugs. Degradation of serum free TAC concentration in the treated group The serum free TAC concentration in the treated group was 1.46±0.27 microg/ml for the whole group, and was significantly higher than that seen in the controls (1.12±0.22 microg/ml) of lisinopril hctz buy online 4.0±1.0 and 4.8±0.9 microg/ml, respectively (p<0.001). Hepatic fibrosis in the treated group Hepatic fibrosis was observed in 17 out of the 18 treated rats. These fibroids were not confined to the liver and extended into pancreas, mesenteric veins and the aorta (Figure 2a). Of note, an increase in the frequency and severity of liver fibrotic lesions in these animals was observed (p<0.05). The were sacrificed from four to 15 days Buying viagra in juarez after the experiment and histological examination of the liver tissues was performed. After histological study of the liver tissues, it was indicated that, although the size and number of fibroids were comparable in control and treatment groups, they were in a greatly elevated state the treated animals (Figure 2b). Figure 2 Hepatic fibrosis in the treated rats. Sixty six out of 69 animal were examined for hepatic fibrosis (a–e). The number of liver fibroids was measured and histological analysis performed on the left and right panels. In the Lisinopril 10mg $92.94 - $1.03 Per pill control group liver fibroses were only observed in two out of six rats, while in the treated group liver fibroids were also observed in all these six rats (b,c). Scale bars: a, 20 µm; b, 1 c, 5 µm. The thickness of skin covering is indicated in the insets of images (b) and (d) by 'circles' 'dashes'. Full size image The level of protein carbonyl content was not significantly.
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